Low-Dose Recombinant Tissue-Type Plasminogen Activator Enhances Clot Resolution in Brain Hemorrhage
نویسندگان
چکیده
منابع مشابه
Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial.
BACKGROUND AND PURPOSE Patients with intracerebral hemorrhage and intraventricular hemorrhage have a reported mortality of 50% to 80%. We evaluated a clot lytic treatment strategy for these patients in terms of mortality, ventricular infection, and bleeding safety events, and for its effect on the rate of intraventricular clot lysis. METHODS Forty-eight patients were enrolled at 14 centers an...
متن کاملMajor Clinical Trial Low-Dose Recombinant Tissue-Type Plasminogen Activator Enhances Clot Resolution in Brain Hemorrhage The Intraventricular Hemorrhage Thrombolysis Trial
Neal Naff, MD; Michael A. Williams, MD; Penelope M. Keyl, PhD; Stanley Tuhrim, MD; M. Ross Bullock, MD; Stephan A. Mayer, MD; William Coplin, MD; Raj Narayan, MD; Stephen Haines, MD; Salvador Cruz-Flores, MD; Mario Zuccarello, MD; David Brock, MD; Issam Awad, MD; Wendy C. Ziai, MD, MPH; Anthony Marmarou, PhD; Denise Rhoney, PharmD; Nichol McBee, MPH, CCRP; Karen Lane, CCRP; Daniel F. Hanley, Jr...
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BACKGROUND Suprachoroidal hemorrhages are a vision-threatening complication, and poor visual outcome is correlated with increasing hemorrhage complexity. The recommended time of surgical drainage is 10-14 days after the hemorrhage begins to liquefy. We describe a case in which recombinant tissue plasminogen activator (r-tPA), alteplase, is injected within the suprachoroidal space before surgery...
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Low molecular size additives such as L-arginine and the redox compounds have been used both in the culturemedium and in vitro refolding to increase recombinant proteins production. Additives increase proteinrefolding and yield of active proteins by suppressing aggregate formation or enhancing refolding process.In this work, a comparative study was performed on refolding of rec...
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A 75-year-old man with end-stage renal disease presented with a 6-month history of nonhealing, markedly painful, necrotic ulcerations of the lower extremities (Figure 1A). The ulceration progressed in spite of multiple treatments elsewhere that included intensive wound care with wet-to-dry dressings, topical becaplermin, surgical debridement, and Unna boot dressings. A skin biopsy specimen demo...
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ژورنال
عنوان ژورنال: Stroke
سال: 2011
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.110.610949